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In preclinical models with an acute diet-induced liver injury model due to a single high-dose fructose binge in mice, as well as a chronic mouse feeding model incorporating fructose intended to mirror early MASLD with features of steatohepatitis, Retatrutide reduced the expression of hepatic inflammation markers chemokine ligand-1 (Cxcl-1), serum amyloid A1 (Saa-1), and serum amyloid A2 (Saa-2) (53)
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Obesity 28(6):10501061 Kusminski CM, Perez-Tilve D, Mller TD, DiMarchi RD, Tschp MH, Scherer PE (2024) Transforming obesity: The advancement of multi-receptor drugs
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